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研究发现关节炎治疗药物可促进脂肪信号传递并能对抗肥胖小鼠的糖尿病_我的网站

刘銮雄太太第三胎

一 | Saiyaara actors Ahaan Panday and Aneet Padda have surpassed big names such as Aamir Khan and Rishab Shetty, securing the top two positions on IMDb's Most Popular Indian Stars of 2025 list, after the huge success of their romantic drama. IMDb recently announced the most popular Indian stars of 2025, determined by page views from over 250 million monthly visitors globally and Ahaan and Aneet secured the top two positions. In the list, Aamir Khan is positioned at number three, followed by Ishaan Khatter and Lakshya in the fourth and fifth spots, respectively. Rashmika Mandanna holds the sixth position, with Kalyani Priyadarshan at seventh. Triptii Dimri, Rukmini Vasanth, and Rishab Shetty complete the list, occupying the eighth, ninth, and tenth places. Ahaan and Aneet are delighted to have secured the top positions and expressed their gratitude to Saiyaara director Mohit Suri for his confidence in their abilities. Ahaan shared, “This is deeply humbling for me. To be ranked No. 1 on the list with my first film is nothing short of a dream come true and a full circle Paulo Coelho moment. But truly, if anything, this recognition makes me a little more aware of the responsibility I have towards my craft, and at the same time, it excites me for what’s to come.” He added, “I would like to thank my director Mohit Suri for allowing me to add to his canvas. Whatever I did on screen was a reflection of his guidance and his genius… I look forward to returning soon with my second film, and this honour is motivation enough to try and deliver a performance that will resonate deeply.” Aneet expressed her gratitude, saying, “Saiyaara changed my life in ways I am only beginning to understand, and to know that people across countries and languages connected with my work means more to me than I can explain.” She added, “I am deeply grateful to everyone who found something to love in Vaani. Your warmth has made this moment possible for me. I want to thank Mohit Suri for seeing something in me before I saw it in myself. The faith in his eyes on set gave me a strange, steady courage. Saiyaara made me braver as an actor.” Also Read: Photos: Ahaan Panday and Aneet Padda’s Sweet Fan Moment Goes Viral。

二 | 在贝勒医学院研究人员的领导下，这项研究源于围绕炎症在胰岛素抵抗中所扮演的角色的新兴知识，以及如何将控制炎症的药物用于对抗糖尿病。作为糖尿病的一个特征，胰岛素抵抗是指细胞无法对激素做出反应并从血液中吸收葡萄糖，而研究已经在它和白色脂肪组织的炎症之间建立了联系。为了更好地了解这些关联，该研究的作者在现有的药物数据库中进行筛选，寻找一种可能同时影响炎症和糖尿病的药物。

三 | 第一作者和共同通讯作者Aaron R. Cox博士说：“我们通过计算筛选了一个小分子数据集，并确定了auranofin，这是一种美国食品和药物管理局批准的药物，已被用于治疗类风湿性关节炎，一种涉及炎症的疾病。Auranofin具有抗炎特性，许多人怀疑这对肥胖症和糖尿病有益；然而，对于它如何影响新陈代谢，人们并不了解。”科学家们用Auranofin治疗糖尿病小鼠模型，并仔细检查了代谢效果，让这些动物食用高脂肪饮食。其中一个关键的发现集中在一种叫做瘦素的激素上，这种激素由脂肪细胞产生，并向大脑发出信号，表明我们已经吃饱。在拥有更多脂肪细胞的肥胖受试者中，瘦素水平升高，打破了这些与大脑的沟通，导致他们通过所谓的瘦素抵抗而暴饮暴食。研究发现Auranofin能降低肥胖小鼠的瘦素水平。该药物还改善了白色脂肪组织的代谢信号，促进了更高的脂肪燃烧率，改善了胰岛素敏感性，并对抗了其他与肥胖有关的影响。